Bayern Munich boss Thomas Tuchel has admitted Harry Kane will miss the last game of the Bundesliga season.
Kane has been ruled out with a back problem, ending any chance of becoming the league's top scorer in a single season.
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Tuchel said: "Harry is receiving treatment from his personal doctor. He cannot travel.
"He was already at the limit in Madrid. He had a complete blockade in his back, it's gotten worse and bothers him in everyday movements."
Bayern take on Hoffenheim away from home in their last game of the season with the Bundesliga 2023/24 campaign drawing to a close.
It has been a disappointing one for the German giants, who lost their title to Bayer Leverkusen this year and were knocked out of the Champions League as Kane's hunt for a trophy goes on.
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And he has further been spurned by an injury that has ruled him out of Saturday's clash that ends his slim chances of beating Robert Lewandowski's incredible Bundesliga record.
In 2020/21, the Poland international netted a whopping 41 times in a single campaign - a record in the Bundesliga - while Kane currently sits on 36 for the season.
It means that if the 30-year-old scored six on Saturday, it would have seen him nudge ahead of Lewandowski's record, something he had been gunning for most of the season.
While that would have been an extremely unlikely scenario anyway, those chances have gone from minuscule to nothing after Tuchel admitted he would not take part on Saturday.
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But Kane is not the only one missing in what will also be Tuchel's last game as manager of Bayern after just one year.
Tuchel further stated: "Leroy Sane and Jamal Musiala won't be in the squad. Eric Maxim Choupo-Moting has the flu and won't be available. Kim Min-Jae is injured and not in the squad.
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"Sacha Boey is definitely not in the squad, for private, sad reasons.
"Raphael Guerreiro and Serge Gnabry are injured. Kingsley Coman is trying everything to be at the Euros, but won't be in the squad tomorrow."
Bayern's season basically finished when they were being knocked out by Real Madrid in the Champions League semi-final.
A late double from Stoke and Newcastle flop Joselu saw the German giants crash out of the competition, leaving Kane devastated.
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It sets up a Champions League final between Real Madrid and Borussia Dortmund at Wembley on June 1 with an Englishman set to lift the trophy no matter what.
Jude Bellingham has been a key performer for Real this season while Jadon Sancho was pivotal against Paris Saint-Germain having joined Dortmund on loan from Manchester United.